Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth

Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via conventional antibody regimens owing to the intracellular location restricting conventional-antibody accessibility. Here, we report a pan-RAS–targeting IgG antibody, inRas37, which directly targets the intracellularly activated form of various RASMUT subtypes after tumor cell–specific internalization into the cytosol to block the interactions with effector proteins, thereby suppressing the downstream signaling. Systemic administration of inRas37 exerted a potent antitumor activity in a subset of RASMUT tumor xenografts in mice, but little efficacy in RASMUT tumors with concurrent downstream PI3K mutations, which were overcome by combination with a PI3K inhibitor. The YAP1 protein was up-regulated as an adaptive resistance-inducing response to inRas37 in RASMUT-dependent colorectal tumors; accordingly, a combination of inRas37 with a YAP1 inhibitor manifested synergistic antitumor effects in vitro and in vivo. Our study offers a promising pan-RAS–targeting antibody and the corresponding therapeutic strategy against RASMUT tumors. Oncogenic mutations in RAS genes (KRAS, NRAS, and HRAS) are found in approxi...

Middle East and Africa Colorants Market Size, Opportunity, Share, Growth, Status, Demand, and Forecast Analysis

The study includes an analysis of market growth drivers, opportunities, challenges, restraints, trends, key strategies, market share, geographical analysis, and many more. Also, the study has focused on market size for various segments that are part of the industry. Analyzing the market on the basis of the competitive landscape provides a correct and real-time picture of the market matrix. The growth rate of the industry in coming years play an important role for investors, manufacturers, and stockholders to decide, whether it is the right time to invest in a particular market or not, this study also has focused on the growth rate of the market during the forecast period. For more info click here @ https://www.reportocean.com/industry-verticals/details?report_id=11866 By Color (Natural Color, Synthetic Color), Product (Pigments, Dyes, Color concentrates, Masterbatches), End-User (Packaging, Paper & Printing, Textiles, Building & Construction, Automotive, Consumer Goods, Others), Country (U.A.E., Saudi Arabia, Israel, Egypt, South Africa and rest of Middle East & Africa) Industry Trends and Forecast to 2026. Colorant is a substance that is used in order to change the ...